Accession Number : ADA271882


Title :   Role of Infection Due to Campylobacter jejuni in the Initiation of Guillain-Barre Syndrome


Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER NASHVILLE TN


Personal Author(s) : Mishu, Ban ; Blaser, Martin J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a271882.pdf


Report Date : Jan 1993


Pagination or Media Count : 7


Abstract : Recent reports suggest that infection with Campylobacter jejuni, a common enteric pathogen, may cause Guillain-Barre syndrome (GBS) by triggering demyelination of peripheral nerves. GBS is preceded by an acute infectious illness (due to a variety of agents) in 50%-75% of cases the onset of neurological symptoms is preceded bt diarrhea in 10%-30% of cases. In the last decade, more than 20 published anecdotal reports and case series have described patients with C. jejuni infectious documented 1-3 weeks before onset of GBS. Cultures of fecal samples obtained at the onset of neurological symptoms from patients with GBS have yielded C. jejuni in more than 25% of cases. A relatively rare serotype, Penner type 019, is over represented among isolates of C. jejuni from Japanese patients with GBS. Serological studies suggest that 20%-40% of patients with GBS have evidence of recent C. jejuni infection. In summary, infection with C. jejuni is a common antecedent to GBS and probably plays a role initiating demyelination; although several pathogenic mechanisms are possible, none has been proven.


Descriptors :   *DIARRHEA , *INFECTIOUS DISEASES , *VACCINES , REPRINTS , PATIENTS , LABORATORY ANIMALS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE