Accession Number : ADA269769


Title :   Mechanisms of Cytotoxicity of the Aids Virus


Descriptive Note : Annual rept. 17 Sep 1991-16 Sep 1992


Corporate Author : WASHINGTON UNIV ST LOUIS MO DIV OF HEMATOLOGY-ONCOLOGY


Personal Author(s) : Ratner, Lee


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a269769.pdf


Report Date : 10 Oct 1992


Pagination or Media Count : 166


Abstract : Regulatory genes of HIV-1, HIV-2, and SIV are important in modulating virus infection and infection and transmission in vivo. Viral proteins R (VPR) and X (VPX) and the negative factor-(NEF) are three of the least well characterized regulatory proteins. Identification of their functions, their mechanisms of actions, and structure-function relationships of each protein, in vitro and in vivo will assist in our understanding of the pathogenesis of HIV- induced disease. This information will be critical in defining therapeutic approaches to suppression HIV-1 infection, replication, and transmission. VPR, VPX, NEF, HIV-1, VPU, AIDS, Cytotoxicity, Biology, Biotechnology, RAD I


Descriptors :   *TOXICITY , *PROTEINS , *HUMAN IMMUNODEFICIENCY VIRUSES , *CELLS(BIOLOGY) , FUNCTIONS , GENES , PATHOGENESIS , APPROACH , ACQUIRED IMMUNE DEFICIENCY SYNDROME , SUPPRESSION , VIRUS DISEASES , BIOTECHNOLOGY , IDENTIFICATION , BIOLOGY


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE