Accession Number : ADA269725


Title :   Molecular Studies of HTLV-1 Infection in Newly Recognized High Risk Population


Descriptive Note : Final rept. 16 Oct 1991-9 Jun 1993


Corporate Author : TEL-AVIV UNIV (ISRAEL)


Personal Author(s) : Danon, Yehuda


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a269725.pdf


Report Date : 10 Jul 1993


Pagination or Media Count : 105


Abstract : The report summarizes the two years of contract of the research aimed to define newly recognized high risk population for HTLV-I infection. To define the extent of HTLV-I infection among groups of Jewish immigrants to Israel with an increased frequency of Adult T-cell Leukemia (ATL). Various serological and molecular screening of methods were used, including ELISA and PCR use for molecular survey by amplification of HTLV-I proviral DNA from peripheral blood mononuclear cells DNA. overall rate of infection is 12% for Jews arriving from Khurusan-North-Eastern Iran. No positive HTLV-I carries were found from other parts of Iran, Ethiopia, and other Mid-Eastern countries, We could not identify HTLV-I seropositive patients in Insulin Dependent DiabeteS Mellitus (IDDM) patients in children with non-Burkitt lymphomas, Psoriasis and Parapsoriasis patients, DNA Sequence data for HTLV-I isolates are provided showing similar sequence to African isolates. HTLV-I, Epidemiology, Polymerase, Virus, Aids, Biotechnology, RAD I.


Descriptors :   *MOLECULAR BIOLOGY , *HUMAN IMMUNODEFICIENCY VIRUSES , *EPIDEMIOLOGY , *LYMPHOMAS , *LEUKEMIA , *ACQUIRED IMMUNE DEFICIENCY SYNDROME , FREQUENCY , ISRAEL , RISK , MIDDLE EAST , CELLS , PATIENTS , BIOTECHNOLOGY , AFRICANS , NUCLEOTIDES , INSULIN , CHILDREN , BLOOD , DIABETES , ADULTS , SEROLOGY , IRAN , JEWS , ETHIOPIA , VIRUSES , AMPLIFICATION , ENZYMES , RATES , POPULATION , SEQUENCES , SURVEYS


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE