Accession Number : ADA268708


Title :   Alterations in Intestinal Permeability After Thermal Injury,


Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAMHOUSTON TX


Personal Author(s) : LeVoyer, Thomas ; Cioffi, W G ; Pratt, Laura ; Shippee, Ronald ; McManus, William F


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a268708.pdf


Report Date : Jan 1992


Pagination or Media Count : 5


Abstract : Alterations in intestinal permeability have been postulated to occur after thermal injury. We evaluated the status of intestinal permeability during the first 2 postburn weeks in 15 subjects by measuring the differential excretion of enterally administered lactulose and mannitol. The mean age and burn size of the patients were 32.7 + or - 3.6 years and 53.3% + or - 5.1% of the total body surface area, respectively. Ten healthy volunteers were also studied. The lactulose mannitol excretion ratio was 0.159 + or - 0.017 for the patients and 0.01 7 -- 0.003 for controls. The increased ratio did not correlate with burn size or postburn day. Patients who developed significant clinical infections during their first 2 postburn weeks had lactulose-mannitol ratios on postburn day 2 that were significantly higher than those of controls and patients who did not develop infections. This suggests a relationship between susceptibility to infection and early alterations in intestinal permeability.


Descriptors :   *WOUNDS AND INJURIES , *RESPONSE(BIOLOGY) , *GASTROINTESTINAL DISEASES , *BURNS(INJURIES) , CONTROL , RATIOS , PERMEABILITY , BACTERIA , VOLUNTEERS , SURFACES , MEAN , PATIENTS , IMMUNITY , BODIES , INTESTINES , HOSTS(BIOLOGY) , EXCRETION , LYMPH NODES , MANNITOL


Subject Categories : Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE