Accession Number : ADA268491


Title :   Hematopoietic Growth Factors and Glucocorticoids Synergize to Mimic the Effects of IL-1 on Granulocyte Differentiation and IL-1 Receptor Induction on Bone Marrow Cells In Vivo


Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD


Personal Author(s) : Dubois, Claire M ; Neta, Ruth ; Keller, Jonathan R ; Jacobson, Sten E ; Oppenheim, Joost J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a268491.pdf


Report Date : Jan 1993


Pagination or Media Count : 10


Abstract : The mechanisms by which interleukin-1 (IL-1) stimulates hematopoiesis are not clear. We have previously shown that in vivo administration of IL-1 indirectly increases IL-1 receptor (IL-1R) expression on both immature and mature bone marrow (BM) cells, partly due to IL-1-induced hematopoietic growth factor (HGF) production. Because IL-1 also stimulates the hypothalamic pituitary-adrenal axis resulting in the production of glucocorticoids (GC), we assessed whether in vivo treatment with HGF and glucocorticoids upregulates IL- IR. Administration of IL-1 to adrenalectomized mice reduces by 53% IL-specific binding on light density bone marrow (LDBM) cells compared to sham-operated mice. The administration of dexamethasone (dex) alone induced only a slight increase in IL-IR expression but synergized with granulocyte colony-stimulating factor (G-CSF), granulocytemacrophage CSF (GM-CSF), IL-3 and IL-6 to upregulate IL-1R expression.


Descriptors :   *IN VIVO ANALYSIS , *BONE MARROW , *HEMATOPOIETIC CELLS , *HEMATOPOIESIS , REPRINTS , DENSITY , MANAGEMENT , GRANULOCYTES , CHEMOTHERAPEUTIC AGENTS , GROWTH(PHYSIOLOGY) , RECEPTOR SITES(PHYSIOLOGY) , CELLS(BIOLOGY) , PRODUCTION , LIGHT , MICE


Subject Categories : Medicine and Medical Research
      Radiobiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE