Accession Number : ADA268189


Title :   Cellular and Molecular Level Responses After Radiofrequency Radiation Exposure, Alone or in Combination with X-rays or Chemicals


Descriptive Note : Annual technical 1 Apr 1992-31 Mar 1993


Corporate Author : TEXAS UNIV HEALTH SCIENCE CENTER AT SAN ANTONIO


Personal Author(s) : Meltz, Martin L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a268189.pdf


Report Date : 27 Jul 1992


Pagination or Media Count : 95


Abstract : The focus of the second years' activities has been to establish, for the human 244B human lymphoblastoid cell line, selected biological effects of standard dose rate ionizing radiation (over the same low total dose range as to be used for combined microwave/ionizing radiation experiments) and hyperthermia (at the same temperature as will be used in the combined studies). Th endpoints which have been examined, and for which alterations have been observed after either ionizing radiation exposure or heat treatment (for different times and temperatures), include cell proliferation and viability, cell cycle distribution, cell surface membrane markers, stress protein synthesis, DNA binding protein induction (NF-kB), and proto-oncogene induction. The observation of the two latter endpoints, at low doses, was unexpected. An interaction of ionizing radiation and hyperthermia, reducing stress protein synthesis, was also unexpected. Of the final 10 surface markers examined, 4 have been identified for their potential use in detecting either ionizing radiation or hyperthermia effects.


Descriptors :   *EXPOSURE(PHYSIOLOGY) , *RADIOFREQUENCY , *RADIATION EFFECTS , RADIATION , TEMPERATURE , DISTRIBUTION , HUMANS , INTERACTIONS , CELLS , PROTEINS , DOSE RATE , LYMPHOCYTES , IONIZING RADIATION , HYPERTHERMIA , MOLECULAR PROPERTIES , CELLS(BIOLOGY) , OBSERVATION , MICROWAVES , DEOXYRIBONUCLEIC ACIDS , HEAT TREATMENT , MEMBRANES , MARKERS


Subject Categories : Anatomy and Physiology
      Radiation Pollution and Control


Distribution Statement : APPROVED FOR PUBLIC RELEASE