Accession Number : ADA267995


Title :   Synthesis of N-(1-Benzyl)-4-Methoxycarbonyl-4-Piperidinyl N- Phenylpropanamide


Descriptive Note : Final rept. May 1991-May 1992


Corporate Author : EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUND MD


Personal Author(s) : McClure, Cynthia K ; Kiessling, Anthony J ; Banks, Harold D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a267995.pdf


Report Date : May 1993


Pagination or Media Count : 17


Abstract : Conditions have been identified for optimization of the hydrolysis of the key alpha-aminonitrile intermediate in the synthesis of the title compound. An extensive search of the literature has discovered an unusual methoxycarbonyl anion equivalent which has been examined by means of a readily available model for addition to the corresponding imine.


Descriptors :   *HYDROLYSIS , *PHENYL RADICALS , *BENZYL RADICALS , *CARBONYL COMPOUNDS , *PIPERIDINES , OPTIMIZATION , MODELS , ANALGESICS , ADDITION , NITRILES , ANIONS , IMINES , SYNTHESIS , AMIDES


Subject Categories : Pharmacology
      Organic Chemistry
      Physical Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE