Accession Number : ADA267262


Title :   Efficacy of Allogenic Cultured Keratinocyte Grafts for Burn Wounds


Descriptive Note : Midterm rept. 3 May 1991-2 May 1993


Corporate Author : NORTH CAROLINA UNIV AT CHAPEL HILL


Personal Author(s) : Meyer, Anthony A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a267262.pdf


Report Date : 01 Jun 1993


Pagination or Media Count : 12


Abstract : Our initial proposal reviewed the previous work on cultured keratinocyte grafts, specifically allografts, done over the last 15 years. The principal hypothesis of this proposal was that although keratinocytes do not express Class II histocompatibility antigens in vitro, once animals are grafted with allogeneic cultured keratinocytes these keratinocytes will sensitize the animals and lead to subsequent rejection. If this hypothesis is not true, however, keratinocyte grafts could be used as a major source of wound coverage for patients with large burns or other open wounds. This Midterm Report will review the progress on this grant as it relates to the initial proposal.... RAII, Lab Animals, Mice, Burns, Allografts, Transplants, Immunohistology.


Descriptors :   *BURNS(INJURIES) , *SKIN GRAFTS , *HISTOCOMPATIBILITY , *SURGICAL TRANSPLANTATION , IN VITRO ANALYSIS , STRAINS(BIOLOGY) , ANTIBODIES , CYTOTOXINS , MICE , ANTIGENS , REJECTION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE