Accession Number : ADA267058


Title :   Novel Approaches to the Synthesis of Carfentanil


Descriptive Note : Final rept. May 1991-May 1992


Corporate Author : EDGEWOOD RESEARCH DEVELOPMENT AND ENGINEERING CENTER ABERDEEN PROVING GROUNDMD


Personal Author(s) : Fraser-Reid, Bertrand O ; Taba, Kalula ; Banks, Harold D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a267058.pdf


Report Date : May 1993


Pagination or Media Count : 22


Abstract : Three novel approaches to the synthesis of carfentanil were investigated that did not involve the hydrolysis of the corresponding a- aminonitrile. Starting with commercially available 1-benzyl-4-piperidone, regioselective cleavage of an a,B-exoxysulfone, an aza (3.3) sigmatropic rearrangement and aminolysis of a 1-bromo-1,2-diene were studied. Of these, the most promising was the sigmatropic rearrangement.... Carfentanil, Aza sigmatropic rearrangement, Piperidine.


Descriptors :   *SYNTHESIS(CHEMISTRY) , *ANALGESICS , SYNTHESIS , STARTING , HYDROLYSIS , PHARMACOLOGY , CLEAVAGE , DIENES , APPROACH , MORPHINE , PIPERIDINES


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE