Accession Number : ADA267047


Title :   Effect of Prolonged Administration of Iodine Containing Water Purification Tablets in Man


Descriptive Note : Final rept.,


Corporate Author : FITZSIMONS ARMY MEDICAL CENTER AURORA CO


Personal Author(s) : Lemar, Homer J , Jr ; Georgitis, William J ; McDermott, Michael T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a267047.pdf


Report Date : 15 Apr 1993


Pagination or Media Count : 7


Abstract : Tetraglycine hydroperiodide tablets purify water by liberating 8 milligrams of iodine per tablet. The effects on thyroid size, function , and iodine uptake resulting from ingestion of four of these tablets daily for three months were studied in eight healthy volunteers. Thyroid size was determined by ultrasound. The thyroid-pituitary axis was assessed by bolus thyrotropin releasing hormone (TRH) tests. Urinary iodide levels increased from 0.276 to 40 mg/d. The mean RAIU fell and remained less than 2%. As thyroxine levels declined, basal thyroid stimulating hormone (TSH) and TSH response to TRH rose. In all subjects, thyroid volume increased. No clinical signs of either hyperthyroidism or hypothyroidism occurred. We conclude that in response to a sustained increment in TSH, the normal thyroid enlarges to adapt to the iodine from continuous use of tetraglycine hydroperiodide water purification tablets E R F PAGES RA II, Water quality


Descriptors :   *THYROID GLAND , *PURIFICATION , *IODINE , *WATER QUALITY , TEST AND EVALUATION , IODIDES , THYROXINE , PHYSIOLOGY , HORMONES , THYROTROPIN , DISEASES


Subject Categories : Anatomy and Physiology
      Water Pollution and Control


Distribution Statement : APPROVED FOR PUBLIC RELEASE