Accession Number : ADA266839


Title :   Neuropeptide-Y (NPY) Increases Total Blood Flow in the Tail, and Reduces Cutaneous Microvascular Blood Flow in the Tail and Foot of the Rat


Descriptive Note : Technical rept. 1990-1991,


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Heath, M E ; Thomas, J R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266839.pdf


Report Date : 10 Feb 1993


Pagination or Media Count : 22


Abstract : The purpose of this study was to describe the in vivo effects of neuropeptide-Y (NPY) on total blood f low (BF sub T) and on microvascular skin blood flow (BF sub sk) in appendages of a whole animal model. This study is important to understanding the medical relevance of NPY in cardiovascular physiology. The tail and foot of the rat were used as the model. BF sub sk and skin temperature (T sub sk) were measured on the foot pad and mid-way along the tail with a laser Doppler flowmeter and a 40-gauge thermocouple. BF sub T was measured mid-way along the tail (distal to the laser Doppler flowmeter) via venous occlusion plethysmography. NPY (16, 32, 64 and 128 microgram/kg), norepinephrine (NE) (25, 50, 100, and 400 microgram/kg) , or saline alone was administered i.v. in 300 microliter volume. NE caused marked reductions in blood flow at all three sites. The duration of the contraction was correlated with the dose. NPY caused immediate marked decreases


Descriptors :   *NOREPINEPHRINE , *BLOOD CIRCULATION , TEMPERATURE , RATS , PEPTIDES , IN VIVO ANALYSIS , THERMAL STRESSES , SKIN(ANATOMY) , LASER VELOCIMETERS , PLETHYSMOGRAPHY , APPENDAGES , CARDIOVASCULAR AGENTS , BODY TEMPERATURE , SKIN DISEASES , COLD TOLERANCE , HOMOGENEITY , CONTRACTION , FLOWMETERS , THERMOCOUPLES , PHYSIOLOGY , SITES , REDUCTION


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE