Accession Number : ADA266510


Title :   Plasmodium vivax VK247 and VK210 Circumsporozoite Proteins in Anopheles Mosquitoes from Andoas, Peru


Descriptive Note : Journal article,


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Need, James T ; Wirtz, Robert A ; Franke, Eileen D ; Fernandez, Roberto ; Carbajal, Faustino


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266510.pdf


Report Date : Jan 1993


Pagination or Media Count : 6


Abstract : Anopheles mosquitoes captured in Andoas, Peru, a Plasmodium vivax- endemic area in the Peruvian Amazon region, contained both VK210 and VK247 P. vivax circumsporozoite (CS) proteins. Approximately 0.9% of the 4,403 mosquitoes tested by enzyme-linked immunosorbent assay were positive; 28% and 72% of the positive mosquitoes contained VK210 and VK247 CS proteins, respectively. These findings correlate strongly with a recent report of the presence of antibodies in residents of this area that recognize the VK210 and VK247 repeats, clearly indicating that both P. vivax CS protein polymorphs are common in the region.... Anopheles, Plasmodium spp., Circumsporozoite.


Descriptors :   *ANTIBODIES , *CULICIDAE , *PLASMODIUM VIVAX , REPRINTS , ENZYMES , IMMUNOASSAY , TAXONOMY , ANOPHELES , POLYMORPHISM , PERU , ANTIGENS , SPOROZOITES , PROTEINS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE