Accession Number : ADA266475


Title :   Delayed Resuscitation with Hypertonic Saline/Dextran from Uncontrolled Aortotomy Hemorrhage in Swine


Descriptive Note : Rept. for Jun 1990-Jun 1992


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : O'Benar, John D ; Bruttig, Stephen P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266475.pdf


Report Date : 29 Jan 1993


Pagination or Media Count : 19


Abstract : Immediate resuscitation from hemorrhage, a common therapy in clinical practice, is associated with high mortality in laboratory models of uncontrolled hemorrhage. We hypothesized that a delayed resuscitation might improve survival, and that gradual repletion of vascular volume might be the most beneficial treatment. To investigate delayed resuscitation, we subjected anesthetized swine weighing 35 to 45 kg to wire suture abdominal aortotomy which resulted in an uncontrolled hemorrhage. After a 30 min delay, they were injected with 4 ml/kg intravenous hypertonic saline/dextran solution (7.5% saline in 6% Dextran 70) administered either as a bolus over 1 minute or as a slow infusion over 12 minutes. Survival was enhanced to 63%, 5/8, in the bolus groups and 78%, 7/9, in the slow infusion group over a survival rate of 57%, 8/14, in the untreated controls. These differences in survival were not statistically significant based on the chi-square test


Descriptors :   *DEXTRAN , *TRAUMA , *HEMORRHAGE , *HYPERTONIC , TEST AND EVALUATION , CONTROL , RATES , DELAY , LABORATORIES , BLOOD VOLUME , KIDNEYS , SUTURES , INFUSIONS , SWINE , RESUSCITATION , CHI SQUARE TEST , SALINITY , THERAPY , MILITARY MEDICINE , FUNCTIONS , MODELS


Subject Categories : Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE