Accession Number : ADA266454


Title :   Increased Vascular Resistance with Hemoglobin-Based Oxygen Carriers


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA DIV OF BLOOD RESEARCH


Personal Author(s) : Hess, J R ; MacDonald, V W ; Gomez, C S ; Copper, V


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266454.pdf


Report Date : Jan 1993


Pagination or Media Count : 14


Abstract : Purpose: To compare the effects of resuscitation with hemoglobin- based oxygen-carriers and conventional crystalloid and colloid resuscitation fluids on hemodynamics, oxygen transport, and oxygen consumption in an animal model of the field medical use of these fluids in the treatment of hemorrhagic shock. Protocol: Twenty-eight immature swine were surgically prepared, allowed to recover five days, water deprived for 48 hours, hemorrhaged of 25 m1/kg over one hour, resuscitated promptly with 1) Ringer's lactate, 75 m1/kg, 2) 7% albumin in Ringer's acetate, 25 m1/kg, 3) 9% unmodified hemoglobin in Ringer's acetate, 25 ml/kg, or 4) 9% alpha alpha-crosslinked hemoglobin in Ringer's acetate, 25 ml/kg, observed with three hours of hemodynamic and oxygen transport measurements, and, finally, blood which had been removed previously was returned.


Descriptors :   *HEMOGLOBIN , *BLOOD SUBSTITUTES , MEASUREMENT , TRANSPORT , FLUIDS , COLLOIDS , ALBUMINS , HEMORRHAGIC SHOCK , ENDOTHELIUM , PULMONARY BLOOD CIRCULATION , BLOOD CELLS , LACTATES , VASOCONSTRICTING , RESUSCITATION , HYPERTENSION , OXYGEN CONSUMPTION , RESISTANCE(BIOLOGY) , CARDIOVASCULAR SYSTEM , CONSUMPTION , MEDICAL RESEARCH , BODY FLUIDS


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE