Accession Number : ADA266292


Title :   A Mathematical Model for the Study of Hemorrhagic Shock and Fluid Resuscitation: The Systemic and Pulmonary Vasculature


Descriptive Note : Final rept. 1989-1993


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : Doherty, Tammy J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266292.pdf


Report Date : Jun 1993


Pagination or Media Count : 25


Abstract : In systemic and pulmonary circuit models, the number and configuration of vascular compartments may affect predictions of vascular volume and blood flow. In this paper, we consider various models of the pulmonary and systemic vascular circuits to identify models appropriate for studies of hemorrhage and fluid resuscitation. We found that at least one pulmonary vascular compartment, made up of one resistance and one capacitance element, was required to describe the response of pulmonary blood volume to changes in pulmonary inflow rate (i.e., right heart output). Incorporation of additional pulmonary vascular segments did not alter predictions of pulmonary volume or flow rate. Therefore, one lumped pulmonary vascular compartment appears to be sufficient. It may be necessary to incorporate multiple pulmonary vascular segments, however, for studies of pulmonary transcapillary exchange or cardiovascular control.


Descriptors :   *MATHEMATICAL MODELS , *HEMORRHAGIC SHOCK , *RESUSCITATION , NOREPINEPHRINE , MUSCLES , PULMONARY FUNCTION , EPINEPHRINE , MEDICAL RESEARCH , BODY FLUIDS , CARDIOVASCULAR SYSTEM , BLOOD CIRCULATION


Subject Categories : Anatomy and Physiology
      Numerical Mathematics


Distribution Statement : APPROVED FOR PUBLIC RELEASE