Accession Number : ADA266241


Title :   Neuropathological Consequences of Exposure to Sublethal Doses of Cyanide


Descriptive Note : Final rept. 29 Jan 1990-31 Jul 1992


Corporate Author : KANSAS UNIV MEDICAL CENTER KANSAS CITY


Personal Author(s) : Pazdernik, Thomas L ; Nelson, Stanley R ; Samson, Fred E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266241.pdf


Report Date : 01 Nov 1992


Pagination or Media Count : 65


Abstract : Experiments focused on the effects of cyanide on brain energy metabolism, microdialysis studies (to measure acid products of anaerobic metabolism, brain monoamines and metabolites, redox-active substances and amino acids), edema and histology. Wistar rats were infused iv with sodium cyanide (NaCN) until the animal lost its righting reflex; when righting returned, NaCN infusion was started again. The local cerebral glucose use (LCGU) was measured by the (14C)-2-deoxyglucose (2-DG) procedure. A shift from aerobic to anaerobic metabolism and the oxidation-reduction state of the brain extracellular fluid (ECF) were determined by intracerebral microdialysis. Immediately after iv infusion of NaCN, there is a robust increase in glucose use. Also, there is a dramatic increase, up to 5-fold, in lactate in the ECF indicating an increase in anaerobic metabolism. However, at 60 minutes after NaCN, LCGU is markedly reduced in all 45 brain regions measured, except for choroid plexus. Thus, the expected increase in glucose use as a result of anaerobic metabolism is brief. The marked increase in acid metabolites of dopamine and serotonin suggest that dopamine and serotonin may participate in the reduction.... Cyanide, Local cerebral glucose use, Brain edema, Intracerebral microdialysis, Lactate, Ascorbate, Potassium, Hydrogen Peroxide, Monoamines, Amino acids, RAV


Descriptors :   *BRAIN , *TOXICITY , *NERVOUS SYSTEM DISEASES , *CYANIDES , *METABOLISM , *SUBLETHAL DOSAGE , RATS , PATHOLOGY , POTASSIUM , AMINO ACIDS , ASCORBATES , SODIUM COMPOUNDS , INFUSIONS , HYDROGEN PEROXIDE , LACTATES , REFLEXES , HISTOLOGY , GLUCOSE , METABOLITES , EDEMA , CHOROID PLEXUS , CENTRAL NERVOUS SYSTEM , DOPAMINE , EYE , REDUCTION , OXIDATION , FLUIDS , SEROTONIN


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE