Accession Number : ADA266113


Title :   The Organization of the Suprachiasmatic Circadian Pacemaker of the Rat and Its Regulation by Neurotransmitters and Modulators


Descriptive Note : Annual rept. 1 Apr 1990-31 Mar 1993


Corporate Author : ILLINOIS UNIV AT URBANA DEPT OF CELL AND STRUCTURAL BIOLOGY


Personal Author(s) : Gillette, Martha U ; DeMarco, Steven J ; Ding, Jian M ; Gallman, Eve A ; Faiman, Lia E ; Liu, Chen ; McArthur, Angela J ; Medanic, Marija ; Richard, Daniel ; Tcheng, Thomas K ; Weber, E T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266113.pdf


Report Date : 18 May 1993


Pagination or Media Count : 18


Abstract : The long-term goal of these studies is to understand how cells of the suprachiasmatic nucleus (SCN) are organized to form a 24-h biological clock and what roles specific neurotransmitters and modulators play in timekeeping and resetting processes. We address these questions by assessing the pattern of spontaneous neuronal activity using extracellular and whole cell patch recording techniques in long-lived SCN brain slices from rats. We have observed that a robust pacemaker persists in the ventrolateral region of microdissected SCN and have begun to define the electrophysiological properties of neurons in this region. Further, we are investigating changing sensitivities of the SCN to resetting by exogenous neurotransmitters, such as glutamate, serotonin and neuropeptide Y, across the circadian cycle. Our findings emphasize the complexity of organization and control of mammalian circadian timing.


Descriptors :   *BRAIN , TIME INTERVALS , CIRCADIAN RHYTHMS , RATS , IN VITRO ANALYSIS , MEDICAL RESEARCH , NEUROTRANSMITTERS , MODULATORS , LABORATORY ANIMALS


Subject Categories : Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE