Accession Number : ADA266059


Title :   Studies of Mechanisms of Pharmacological Enhancement of Functional Recovery After Cortical Contusion


Descriptive Note : Final rept. 4 Jan 1991-31 Dec 1992


Corporate Author : NEW MEXICO UNIV ALBUQUERQUE


Personal Author(s) : Sutton, Richard L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a266059.pdf


Report Date : 29 Jan 1993


Pagination or Media Count : 55


Abstract : Electrophysiology, autoradiography, histochemistry, biochemistry, anatomical, and behavioral research techniques were used in studies to examine remote functional depressions, and the effects of drug treatments on some of these measures, in rats with unilateral ablation of the sensorimotor cortex (SMCx) or traumatic brain injury (contusion; TBI) centered over the SMCx. In addition to d-amphetamine (d-AMPH), drugs increasing norepinephrine (NE) release were found to accelerate beam-walking (BW) recovery in rats with SMCx ablation. The dose of d-AMPH required to induce BW recovery after TBI was dependent upon whether the right or left hemisphere was damaged and/or the extent of damage to midline cortex. Drugs decreasing NE levels or blocking alphal-NE receptors were found to reinstate BW deficits in rats after SMCx ablation.


Descriptors :   *CENTRAL NERVOUS SYSTEM , *PHARMACOLOGY , *BRAIN DAMAGE , ABLATION , RECOVERY , BIOCHEMISTRY , WALKING , METABOLISM , LESIONS , CEREBELLUM , AMPHETAMINES , HISTOCHEMISTRY , AUTORADIOGRAPHY , ELECTROPHYSIOLOGY , BLOOD CIRCULATION , NOREPINEPHRINE , WOUNDS AND INJURIES , PHARMACOKINETICS , DRUGS , PATHOPHYSIOLOGY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE