Accession Number : ADA265972


Title :   Role of Spatially Distributed Ion Channels in Single Neuron Computation


Descriptive Note : Final rept. 1 Mar 1990-15 Dec 1992


Corporate Author : WASHINGTON UNIV SEATTLE DEPT OF PHYSIOLOGY AND BIOPHYSICS


Personal Author(s) : Schwindt, Peter C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a265972.pdf


Report Date : 17 May 1993


Pagination or Media Count : 5


Abstract : Towards the overall goal of making an accurate mathematical model of a neocortical pyramidal neuron, (1) the electrical properties of Na+ and Ca2+ channel subtypes were measured in sufficient detail to construct a quantitative empirical model, and (2) antibodies were raised against the a1 subunits of these channel subtypes in order to determine their spatial distribution and relative density using quantitative immunocytochemistry.... Ion channels, Sodium, Calcium, Electrophysiology, Immunocytochemistry


Descriptors :   *MATHEMATICAL MODELS , *IONS , *CALCIUM , *SODIUM , *ANTIBODIES , SPATIAL DISTRIBUTION , DENSITY , CHANNELS , ELECTROPHYSIOLOGY , ELECTRICAL PROPERTIES


Subject Categories : Atomic and Molecular Physics and Spectroscopy


Distribution Statement : APPROVED FOR PUBLIC RELEASE