Accession Number : ADA265924


Title :   Variations in Time-To-Incapacitation and Blood Cyanide Values for Rats Exposed to Two Hydrogen Cyanide Gas Concentrations


Descriptive Note : Final rept.


Corporate Author : FEDERAL AVIATION ADMINISTRATION WASHINGTON DC OFFICE OF AVIATION MEDICINE


Personal Author(s) : Chaturvedi, Arvind K ; Endecott, Boyd R ; Ritter, Roxane M ; Sanders, Donald C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a265924.pdf


Report Date : May 1993


Pagination or Media Count : 19


Abstract : It has been suggested that protective breathing devices protect aircraft passengers from combustion products for 5 min during evacuation and for 35 min during in-flight-plus-evacuation. Hydrogen cyanide (HCN), a combustion gas, produces incapacitation at relatively low concentrations, and time-to- incapacitation (ti)is an applicable index for predicting escape from a fire. Variations in ti and blood cyanide (CN value) at specific HCN gas exposure concentrations have not been evaluated. Therefore, ti and blood CN value at ti for two HCN concentration that produce 5- and 35- min ti were determined in male Sprague-Dawley rats. Blood CN value levels as a function of HCN exposure time were measured. Animals were individually exposed to HCN gas in a chamber equipped with a rotating cage, and ti recorded as the time from insertion of the animal into the cage until it could no longer walk. At incapacitation and at selected intervals prior to ti, rats were quickly removed from the cage and killed for blood collection and CN value quantitation. Chamber HC concentrations were monitored during the exposures


Descriptors :   *RESPIRATION , *AVIATION SAFETY , *AIRCRAFT FIRES , *COMBUSTION PRODUCTS , *HYDROGEN CYANIDE , NAVAL AVIATION , RATS , COMMERCIAL AVIATION , TIME , AVIATION ACCIDENTS , INFLIGHT , CIVIL AVIATION , IN VIVO ANALYSIS , PASSENGERS , EVACUATION , AIR FORCE OPERATIONS , ARMY AVIATION , LABORATORY ANIMALS , BLOOD GASES , AVIATION INJURIES , INCAPACITATING AGENTS


Subject Categories : Military Aircraft Operations
      Commercial and General Aviation
      Medicine and Medical Research
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE