Accession Number : ADA265569


Title :   Candid No. 1 Argentine Hemorrhagic Fever Vaccine Protects against Lethal Junin Virus Challenge in Rhesus Macaques


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : McKee, Kelly T , Jr ; Barrera Oro, Julio G ; Kuehne, Anna I ; Spisso, Joan A ; Mahlandt, B G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a265569.pdf


Report Date : Jan 1992


Pagination or Media Count : 10


Abstract : The protective efficacy of Candid No.1, a live-attenuated vaccine against Argentine hemorrhagic fever (AHF), was evaluated in non-human primates. Twenty rhesus macaques immunized 3 months previously with graded doses of Candid No. 1( 16 -127, 000 PFU), as well as 4 placebo-inoculated controls, were challenged with 4.41 log10 PFU of virulent P3790 strain Junin virus. All controls developed severe clinical disease; 3 of 4 died. In contrast, all vaccinated animals were fully protected; none developed any signs of AHF during a 105-day follow-up period. Viremia and virus shedding were readily detected in all placebo-vaccinated controls, while virus could be recovered only once (by amplification) from throat swabs of 2 Candid No 1 vaccinees on day 21.


Descriptors :   *HEMORRHAGIC FEVERS , *RHESUS MONKEYS , REPRINTS , MODELS , PROTECTION , VIRUSES , IMMUNIZATION , LIVE VACCINES , MACAQUE MONKEYS , FLUORESCENT ANTIBODY TECHNIQUES , LABORATORY ANIMALS , ARGENTINA , IMMUNITY , ATTENUATION , LETHALITY , PRIMATES


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE