Accession Number : ADA265532


Title :   Studies in Bioorganic Chemistry


Descriptive Note : Final rept.


Corporate Author : PENNSYLVANIA UNIV PHILADELPHIA DEPT OF CHEMISTRY


Personal Author(s) : Winkler, Jeffrey D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a265532.pdf


Report Date : Jun 1993


Pagination or Media Count : 3


Abstract : The grant addressed two issues of fundamental importance in biomimetic chemistry that had not been successfully imitated in a non-enzymatic system at the time at which this project started: the conformational flexibility of the enzyme active site and the consequences of such mobility for catalysis, and the stereoselective formation of carbon-carbon bonds using compounds that are based on the ubiquitous biological methylating agent S-adenosylmethionine. The photodynamic macrocycles that were originally proposed are not only fascinating molecules because of their unique structural effects, but were designed to be useful in the active transport of both metals and organic molecules which would have obvious implications in processes like the extraction of metals and organic molecules from aqueous solutions. The mimics of S- adenosylmethionine that were proposed in the original contract were to be applied to a variety of alkylation reactions, and could ultimately be applied to the development of site-specific reagents for DNA functionalization, thereby providing an important control mechanism for gene expression


Descriptors :   *CATALYSIS , *ENZYME CHEMISTRY , DEOXYRIBONUCLEIC ACIDS , STEREOCHEMISTRY , GENETICS , ALKYLATION


Subject Categories : Biochemistry
      Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE