Accession Number : ADA265410


Title :   Experimental Campylobacter Jejuni Infection in Humans


Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER DENVER CO


Personal Author(s) : Black, Robert E ; Levine, Myron M ; Clements, Mary L ; Hughes, Timothy P ; Blaser, Martin J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a265410.pdf


Report Date : Mar 1988


Pagination or Media Count : 9


Abstract : Two strains of Campylobacter jejuni ingested by 111 adult volunteers, in doses ranging from 8 x 102 to 2 x 109 organisms, caused diarrheal illnesses. Rates of infection increased with dose, but development of illness did not show a clear dose relation. Resulting illnesses with strain A3249 ranged from a few loose stools to dysentery, with an average of five diarrheal stools and a volume of 509 mL. Infection with strain 81-176 was more likely to cause illness, and these illnesses were more severe, with an average of 15 stools and 1484 mL of total stool volume. All patients had fecal leukocytes. The dysenteric nature of the illnesses indicates that the pathogenesis of C. jejuni infection includes tissue inflammation. Ill volunteers developed a serum antibody response to the C. jejuni group antigen and were protected from subsequent illness but not infection with the same strain.


Descriptors :   *DIARRHEA , *INFECTIOUS DISEASES , REPRINTS , HUMANS , BACTERIA , DOSAGE , CULTURES(BIOLOGY) , PATIENTS , STRAINS(BIOLOGY) , VOLUNTEERS , ISOLATION


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE