Accession Number : ADA264851


Title :   Development of Bioelastic Materials for the Prevention of Adhesions: Polypenta- and Polytetrapeptides


Descriptive Note : Final rept. 15 Sep 89-14 Mar 93.


Corporate Author : BIOELASTICS RESEARCH LTD BIRMINGHAM AL


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264851.pdf


Report Date : 14 Mar 1993


Pagination or Media Count : 134


Abstract : The purpose of the contract was the development of bioelastic materials for the application of preventing post-surgical and post-trauma adhesions by preparing compliant sheets which can be placed between repair sites and which act as barriers to the formation of adhesions between the repairing sites. Specifically to be prepared were quantities of a series of polypentapeptides and polytetrapeptides which were gamma-irradiation cross- linked to form elastomeric sheets and which were supplied to the Naval Medical Research and Development Command, Combat Casualty Care Unit for the animal model efficacy studies carried out at the Naval Medical Research Institute. In addition, in the process of carrying out the specific objectives, considerations of further applications was stimulated and these stimuli, coming from interactions with Navy personnel and others, have resulted in the development of intellectual property with the support of this contract.


Descriptors :   *PEPTIDES , *POLYMERS , *ELASTOMERS , *ADHESION , *BIOLOGICAL PRODUCTS , MODELS , SHEETS , HYDROPHOBIC PROPERTIES , LABORATORY ANIMALS , BARRIERS , CROSSLINKING(CHEMISTRY) , ELASTIC PROPERTIES , COMPOSITE MATERIALS , PROTEINS


Subject Categories : Biochemistry
      Pharmacology
      Polymer Chemistry
      Elastomers and Rubber


Distribution Statement : APPROVED FOR PUBLIC RELEASE