Accession Number : ADA264779


Title :   T Cell Recognition of Mls-like Superantigens: Analysis of TCR requirements, Superantigenic Ligands, and Signal Transduction


Descriptive Note : Journal article


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Hodes, Richard J ; Abe, Ryo


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264779.pdf


Report Date : Jan 1992


Pagination or Media Count : 10


Abstract : Mls-like endogenous superantigens have been reported to be unique, differing from conventional antigens in the T cell receptor (TCR) requirements for their recognition, in the signal transduction events which they elicit in T cells, and in the identity of the stimulatory ligand. This review describes recent findings indicating that TCR V(alpha) as well as V(beta) products play a role in mls recognition. Data are also summarized which indicate that T cell recognition of Mls leads to increased intra-cellular (Ca2(+)) and phosphatidyl inosotol hydrolysis. Finally, genetic linkage between mouse mammary tumor virus (MMTV) proviruses and endogenous superantigens is analyzed, and the possible role of non-MMTV products is examined.


Descriptors :   *ANTIGENS , *LYMPHOCYTES , REPRINTS , IN VITRO ANALYSIS , STRAINS(BIOLOGY) , GENES , POLYMORPHISM , RECEPTOR SITES(PHYSIOLOGY) , CLONES , T LYMPHOCYTES , IN VIVO ANALYSIS , CELLS(BIOLOGY)


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE