Accession Number : ADA264666


Title :   Inhibition of DNA Binding by the Phosphorylation of Poly ADP-Ribose Polymerase Protein Catalyzed by Protein Kinase C


Descriptive Note : Annual rept. 1 Apr 92-31 Mar 93,


Corporate Author : SAN FRANCISCO STATE UNIV TIBURON CA ROMBERG TIBURON CENTERS


Personal Author(s) : Kun, Ernest


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264666.pdf


Report Date : 21 Apr 1993


Pagination or Media Count : 53


Abstract : Purified type II (beta) and type III (alpha) protein kinase C phosphorylates highly purified polyADP-ribose polymerase in vitro whereby 2 mols of phosphate are transferred from ATP to serine and threonine.


Descriptors :   *DEOXYRIBONUCLEIC ACIDS , *ENZYME INHIBITORS , PROTEINS , IN VITRO ANALYSIS , CATALYSIS , IN VIVO ANALYSIS , CELLS(BIOLOGY) , RIBOSE , THYMUS , PHOSPHORUS TRANSFERASES , RESIDUES , PHOSPHATES , SERINE , ADENOSINE PHOSPHATES , PHOSPHORYLATION


Subject Categories : Biochemistry
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE