Accession Number : ADA264657


Title :   Development of Safe, Effective Vaccines for Dengue Virus Disease by Recombinant Baculovirus


Descriptive Note : Annual rept. 1 Mar 91-28 Feb 92,


Corporate Author : NATIONAL INSTITUTES OF HEALTH BETHESDA MD


Personal Author(s) : Lai, Ching J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264657.pdf


Report Date : 25 Aug 1992


Pagination or Media Count : 29


Abstract : Outbreaks and major epidemics of dengue continue to afflict human populations, especially in the tropical and subtropical regions of the world. Dengue viruses, transmitted predominantly by mosquito species of the Aedes genus, include four serotypes that are distinguishable by plaque reduction-- neutralization with type specific monoclonal antibodies. Dengue is characterized by fever, rash, severe headache, and joint pain. Its mortality rate is low. However, over the past few decades, a more severe form of dengue, characterized by hemorrhage and shock has been observed with increasing frequency in children and young adults. This severe form of dengue has a high mortality rate. Despite years of intensive research, an effective vaccine is still not available for prevention of dengue infection. For these reasons, research on dengue viruses and development of safe and effective vaccines have been given a high priority by the World Health Organization.... Dengue virus, Genetic engineering, Recombinant DNA, Vaccines, Biotechnology, Diseases, ID, RA I.


Descriptors :   *MONOCLONAL ANTIBODIES , *GENETIC ENGINEERING , *VACCINES , *VACCINIA VIRUS , *SUBTROPICAL REGIONS , *DENGUE VIRUS , FREQUENCY , MEMBRANES(BIOLOGY) , HEALTH , NEUTRALIZATION , RATES , POPULATION , DEOXYRIBONUCLEIC ACIDS , HEADACHES , AEDES , CULICIDAE , HEMORRHAGE , FEVERS , RIBONUCLEIC ACIDS , PREVENTION , MORTALITY RATE , BIOTECHNOLOGY , REGIONS , REDUCTION , SHOCK , GENES , TROPICAL REGIONS , RECOMBINATION REACTIONS , PAIN


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE