Accession Number : ADA264553


Title :   Control and Circadian Behavior by Transplanted Suprachiasmatic Nuclei


Descriptive Note : Final rept. 15 Nov 1989-14 Nov 1992


Corporate Author : VIRGINIA UNIV CHARLOTTESVILLE DEPT OF BIOLOGY


Personal Author(s) : Menaker, Michael


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264553.pdf


Report Date : 14 Nov 1992


Pagination or Media Count : 10


Abstract : Fetal SCN tissue transplanted into the third ventricle of hamsters bearing complete SCN lesions restores the circadian locomotor rhythm with a period that depends exclusively on the genetically determined period of the tissue donor. If the host is only partially lesioned and thus retains rhythmicity with its own genetically determined period, an implant from an animal of a different genotype can induce a second rhythm with a period determined by the donor genotype. Both rhythms can be present simultaneously in the record of such a temporal chimera, interacting only superficially (i.e., not at the level of the pacemaker). Our data support the interpretation that under such circumstances the graft is able to capture part of the locomotor output of the circadian system but does not make functional connections with the host SCN pacemaking system.


Descriptors :   *CIRCADIAN RHYTHMS , *MUTATIONS , *GENETICS , OSCILLATORS , HAMSTERS , SURGICAL TRANSPLANTATION , PACEMAKERS , VENTRICLES , LESIONS , BOUNDARIES , OUTPUT , FUNCTIONS


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE