Accession Number : ADA264517


Title :   Measurement of the Magnetic and Electrical Activity of Individual Cells In Vitro


Descriptive Note : Final rept. 24 Sep 90-23 Sep 92,


Corporate Author : MARYLAND UNIV COLLEGE PARK DEPT OF ELECTRICAL ENGINEERING


Personal Author(s) : Davis, Christopher C


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264517.pdf


Report Date : 26 Feb 1993


Pagination or Media Count : 92


Abstract : This report describes the development of both incoherent and coherent fiber optic sensors for monitoring the electrical activity of cells and tissue. The incoherent sensors use an optical fiber to deliver laser light to a cell membrane that is stained with a voltage-sensitive dye. The change in resulting fluorescence allows the electrical activity of the cell to be monitored. The coherent fiber sensor uses an external element, either a cell or some other material that has induced birefringence, as an extrinsic sensing element. The fiber is a means for delivering coherent light to this element. Birefringence- induced phase changes are detected in a heterodyne interferometric scheme. This report also describes the development work to date on NanoSQUID, a very small scale, superconducting quantum interference device that will allow spatially- resolved measurements of the magnetic activity of cells and tissue. Fiber optic sensors, SQUID magnetometers, Voltage-sensitive dyes, Cellular electrical activity, RA 3.


Descriptors :   *FIBER OPTICS , *MONITORING , *BIOELECTRICITY , MEASUREMENT , LIGHT , LASERS , INTERFERENCE , DYES , MAGNETOMETERS , CELLS(BIOLOGY) , BIREFRINGENCE , IN VITRO ANALYSIS , VOLTAGE , MEMBRANES(BIOLOGY) , FLUORESCENCE


Subject Categories : Biochemistry
      Biomedical Instrumentation and Bioengineering


Distribution Statement : APPROVED FOR PUBLIC RELEASE