Accession Number : ADA264293


Title :   An Assessment of Peripheral Nerve Damage In The Rat Following Non- Freezing Cold Exposure: An Electrophysiological and Histopathological Examination


Descriptive Note : Technical rept. Jan 1991-Jan 1992


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Shurtleff, David ; Gilliatt, Roger W ; Thomas, John R ; Pezeshkpour, G H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264293.pdf


Report Date : 20 Jan 1993


Pagination or Media Count : 21


Abstract : The effect of exposure to non-freezing cold temperature on peripheral nerve was studied in vivo. Rats' tails, and a portion of their lower backs, were submerged in 1 deg. C water for either 10 or 12 hours. Changes in evoked ascending nerve action potentials, and muscle action potentials in the rat tail and lumbar spine, were studied periodically over a three week period following cold exposure. In addition, ventral caudal nerves were excised 27 days following cold exposure and histopathology was performed. Electrophysiological analysis indicated initial nerve damage appeared to be just below the surface of the water, and later, in the first week after exposure, Wallerian degeneration occurred. Histopathological analysis revealed damage to the large myelinated fibers and capillaries within the fascicle following cold exposure. These results further validate the use of the rat tail as a model for non-freezing cold injury (NFCI) and suggest that the injury's etiology is multifaceted, which may require a variety of strategies and interventions to prevent its occurrence. ... Non-freezing injury, Cold injury, Rat caudal nerve, Peripheral nerve function, Conduction studies


Descriptors :   *LOW TEMPERATURE , *HISTOPATHOLOGY , *ELECTROPHYSIOLOGY , *COLD TOLERANCE , FUNCTIONS , STRATEGY , EXPOSURE(GENERAL) , RATS , SURFACES , ETIOLOGY , WOUNDS AND INJURIES , EXPOSURE(PHYSIOLOGY) , PERIPHERAL NERVOUS SYSTEM , SPINAL COLUMN , NERVES , INTERVENTION , IN VIVO ANALYSIS , MUSCLES , NERVE CELLS , FREEZING , WATER , MODELS , DAMAGE , FIBERS


Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE