Accession Number : ADA264291


Title :   Local and Systemic Absorption of Parenteral and Peritoneal Administration of Ceftriaxone in Rats


Descriptive Note : Technical rept. Oct 1991-Oct 1992


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Perdue, P W ; Kurlansik, L ; Mell, L D ; Gallus, D P ; Nevola, J J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264291.pdf


Report Date : 03 Mar 1993


Pagination or Media Count : 15


Abstract : High performance liquid chromatography was used to determine plasma and peritoneal fluid ceftriaxone levels after both parenteral administration and peritoneal irrigation with ceftriaxone. Ceftriaxone in amounts greater than the minimum inhibitory concentration effective against E. coli was detected in plasma of rats that received peritoneal irrigation with 1000 mg/l ceftriaxone solution; there was no ceftriaxone present in plasma of rats that received peritoneal irrigation with 10 mg/l ceftriaxone solution. Lastly, ceftriaxone irrigation was not associated with any increase in the incidence of intraabdominal adhesions in this rat model.... Antibiotic, Endotoxin, Peritoneal, Absorption.


Descriptors :   *LIQUID CHROMATOGRAPHY , *ENDOTOXINS , *ANTIBIOTICS , MANAGEMENT , MODELS , RATS , BACTERIA , ADHESION , ESCHERICHIA COLI , MILITARY MEDICINE , NAVAL RESEARCH , NAVAL OPERATIONS , FLUIDS , ABSORPTION , PATIENTS , BLOOD PLASMA , LABORATORY ANIMALS , GRAM NEGATIVE BACTERIA , GRAM POSITIVE BACTERIA


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE