Accession Number : ADA264288


Title :   Preclinical Pharmacology of Antiviral Agents


Descriptive Note : Final rept. Jul 1990-Dec 1991


Corporate Author : UTAH STATE UNIV LOGAN DEPT OF ANIMAL DAIRY AND VETERINARY SCIENCE


Personal Author(s) : Coulombe, Jr, Roger A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a264288.pdf


Report Date : 11 Dec 1992


Pagination or Media Count : 32


Abstract : The pharmacokinetics of two novel antiviral agents, carobocyclic 3- deazaadenosine (Cc3Ad) and 3-deazaneplanocin (3-DA) was investigated in female BALB/C mice. For the former drug, there was rapid and extensive tissue distribution, an elimination half-life of 23 and 38 min for i.v. and orally- administered drug, respectively. For 3-DA, an elimination half-life of 26 min was found for iv administered drug. 3-DA was less extensively distributed into tissue Cc3Ado was not found to bind to plasma proteins, while 3-DA, at low concentrations of drug bound extensively. Both compounds were metabolized to labeled products, which have not yet been identified. For Cc3Ado, one major metabolite eluted later than the parent compound, whereas in the case of 3-DA, the major labeled compound eluted earlier than the parent. We conclude provisionally that these labeled compounds represent metabolic conversion products. Tissues from mice dosed with either Cc3Ado or 3-DA contained detectable parent drug, but the majority of label represented chromatographic peaks other than the parent drug, indicating that the drugs were significantly metabolized. Antiviral agents, Pharmacokinetics, Carbocyclic 3-deazaadenosine, 3-Deazaneplanocin, Pharmacology, Metabolism, BD, RAI.


Descriptors :   *IN VITRO ANALYSIS , *PHARMACOKINETICS , *IN VIVO ANALYSIS , *PHARMACOLOGY , *ANTIVIRAL AGENTS , *ARBOVIRUSES , CONVERSION , PREDICTIONS , DISTRIBUTION , MICE , INHIBITION , HALF LIFE , BLOOD PROTEINS , BLOOD PLASMA , LABELS , RESPIRATORY DISEASES , METABOLITES , FEMALES , FEVERS , ELIMINATION , MAJORITIES , VIRUSES , DRUGS , INFECTIOUS DISEASES , LETHALITY , TOXICITY , PROTEINS , METABOLISM


Subject Categories : Biochemistry
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE