Accession Number : ADA263193


Title :   Thallium Toxicity: The Problem; An Analytical Approach; An Antidotal Study


Descriptive Note : Master's thesis,


Corporate Author : ARMY STUDENT DETACHMENT FORT BENJAMIN HARRISON IN


Personal Author(s) : Mulkey, James P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a263193.pdf


Report Date : 15 May 1993


Pagination or Media Count : 251


Abstract : Thallium (T1) is a highly toxic metal that is anthropogenically concentrated in the environment. Tl toxicity and the quantitative analysis of trace levels of Tl in biologic materials by atomic absorption spectroscopy is reviewed; a study designed to evaluate the antidotal efficacy of 2 compounds in the treatment of acute Tl toxicity in rats is documented. Unithiol (2,3- dimercapto-1-propanesulfonic acid, DMPS) and prussian blue (potassium ferric hexacyanoferrate(II), PB), given alone and in combination, were evaluated as antidotes in the treatment of acute thallotoxicosis in male Sprauge-Dawley rats. The relative accumulation of Tl in organs was kidneyheartliver-brain. PB induced significant decorporation of Tl from all tissues. DMPS failed to significantly decrease the Tl content in any organ, but significantly decreased the Tl content in whole blood. PB+DMPS treatment significantly decreased the Tl content in all organs, but to no greater extent than PB alone. PB and PB+DMPS treatments significantly increased the Tl content of feces, whereas DMPS treatment alone produced little effect. This study indicates that PB is a beneficial antidote in the treatment of acute thallotoxicosis in rats. The failure of DMPS to significantly decrease the Tl content in 4 target organs suggests it would not be useful in the treatment of Tl poisoning....Thallium, Poison, Antidote, Chelator, Prussian blue, Potassium ferric hexacyanoferrate(II) , Unithiol, 2,3-dimercapto-1-propanesulfonic acid, Rat.


Descriptors :   *METALS , *TOXICITY , *ANTIDOTES , *THALLIUM , QUANTITATIVE ANALYSIS , ENVIRONMENTS , BIOLOGY , FAILURE , TARGETS , ABSORPTION , SULFUR COMPOUNDS , SULFONIC ACIDS , PROPANE , BLOOD , POTASSIUM , POISONS , ATOMIC PROPERTIES , BLUE(COLOR) , ACCUMULATION , MALES , IRON , THESES , BRAIN , RATS , SPECTROSCOPY , MATERIALS


Subject Categories : Toxicology
      Inorganic Chemistry
      Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE