Accession Number : ADA263177


Title :   Effects on Chronic Stress on Anterior Pituitary and Brain Corticotropin- Releasing Factor Receptors,


Descriptive Note : Journal article


Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC


Personal Author(s) : Anderson, Sally M ; Kant, G J ; De Souza, Errol B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a263177.pdf


Report Date : Jan 1993


Pagination or Media Count : 8


Abstract : 125I corticotropin-releasing factor ({125I}CRF) binding was measured in membrane homogenates from anterior pituitary and 8 brain regions from control and chronically stressed rats. The stressor consisted of 3 or 14 days of around-the-clock intermittent footshock avoidance/escape (ITI = 5 min) . Plasma corticosterone levels were almost doubled in stressed rats following 3 days of chronic stress and remained significantly elevated in rats stressed for 14 days vs. controls. {125I}CRF binding was decreased in anterior pituitary and frontal cortex following three days of chronic stress; binding affinity of anterior pituitary membranes was not different between control and stressed animals. {125I}CRF binding was similar in control and 3 day stressed animals in the other brain areas examined. After 14 days of chronic stress, hypothalamic {125I}CRF binding was decreased in stressed rats as compared to control animals but no other differences were seen.... Stress, Corticotropin-releasing factor receptors, CRF, CRH, Corticotropin-releasing hormone, Neuroendocrine factor receptors.


Descriptors :   *STRESS(PHYSIOLOGY) , *PITUITARY GLAND , *RECEPTOR SITES(PHYSIOLOGY) , *ADRENOCORTICOTROPIC HORMONE , CONTROL , REPRINTS , HORMONES , MEMBRANES(BIOLOGY) , ANIMALS , BLOOD PLASMA , OLFACTORY NERVE , CORTICOSTEROID AGENTS , AVOIDANCE , CELLS(BIOLOGY) , REGIONS , SYNTHESIS(CHEMISTRY) , BRAIN , CLOCKS , RATS


Subject Categories : Anatomy and Physiology
      Stress Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE