Accession Number : ADA262974


Title :   Tracheobronchial Mucins in Health, Disease, and Toxic Exposures


Descriptive Note : Final rept. 1 Dec 1990-31 Dec 1992


Corporate Author : WILLIAM BEAUMONT ARMY MEDICAL CENTER ELPASO TX DEPT OF CLINICAL INVESTIGATION


Personal Author(s) : Bhattacharyya, Sambhu N


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a262974.pdf


Report Date : 01 Feb 1993


Pagination or Media Count : 8


Abstract : The major portion of this project, identification of mucin core peptide, raising the antibody against mucin peptide, mucin gene expression in rat tracheal epithelial culture system, has been successfully accomplished. The main discovery in this project is the role of retinoic acid (a component of vitamin A) in maintaining healthy tracheal epithelial cells exposed to different toxic and carcinogenic substances, and use of steroids in suppression of mucin gene expression. Further studies are underway to discern the mechanism involving the role of vitamin A in mucin gene expression in the tracheal epithelial cell system. The environmental research facility and exposure chamber have been completed. Experiments relating to exposure will begin shortly. The last portion of the project could not be accomplished due to the delay in the contracting procedures relating to construction of the environmental facility and exposure chamber.... RA 2, Inhalation toxicology.


Descriptors :   *CLINICAL MEDICINE , *EXPOSURE(PHYSIOLOGY) , *MEDICAL SERVICES , *TOXICOLOGY , *MUCIN , RATS , PEPTIDES , ARMY FACILITIES , DISEASES , RESEARCH FACILITIES , IDENTIFICATION , ANTIBODIES , GENES , CELLS(BIOLOGY) , CULTURE , CHAMBERS , SUPPRESSION , TOXINS AND ANTITOXINS , INHALATION , TOXIC DISEASES , STEROIDS , VITAMIN A


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE