Accession Number : ADA262883


Title :   An Investigation of Resolution as Encountered In Various Chromatographic Operational Modes


Descriptive Note : Final rept. 1 Jan 1991-30 Apr 1992


Corporate Author : DAYTON UNIV OH


Personal Author(s) : Rubey, Wayne A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a262883.pdf


Report Date : Aug 1992


Pagination or Media Count : 75


Abstract : An investigation was performed relative to the generation of resolution in isothermal gas chromatography (ITGC), programmed-temperature gas chromatography (PTGC), and a newly evolving technique referred to as thermal gradient programmed gas chromatography (TGPGC). The generation of chromatographic resolution while using open tubular gas chromatographic columns was studied with respect to the influences of dispersion, selectivity, and solute partitioning. Experiments were subsequently conducted to simulate rapid whole column PTGC operation with lengthy open tubular columns. Close agreement between theory and actual generated resolution was obtained during this simulation activity. The major conclusion from this study was that a partition- ratio programming chromatographic operational mode, e.g., TGPGC, possesses considerable promise with respect to rapidly and effectively eluting solutes. Properly implemented TGPGC should be capable of operation whereby selectivity and partitioning are enacted in a near-optimum manner with respect to obtaining maximum useful resolution per unit time.


Descriptors :   *COMPUTER PROGRAMMING , *SOLUTES , *GAS CHROMATOGRAPHY , SIMULATION , RATIOS , RESOLUTION , GRADIENTS , DISPERSIONS , AGREEMENTS , OPERATION , RATES , TEMPERATURE , THEORY


Subject Categories : Physical Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE