Accession Number : ADA262533


Title :   In Vivo Distribution of Liposome Encapsulated Hemoglobin Studied with Imaging Radiotracers


Descriptive Note : Progress rept


Corporate Author : TEXAS UNIV AT SAN ANTONIO OFFICE OF CONTRACTS AND GRANTS


Personal Author(s) : Phillips, William T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a262533.pdf


Report Date : 29 Mar 1993


Pagination or Media Count : 6


Abstract : This project has as its objective the development of radiotracer imaging technology to follow the in vivo circulation and organ deposition of liposome encapsulated hemoglobin (LEH). LEH will be labeled with technetium-99m (99m Tc) or indium-111 (111In) and infused into small animals to monitor any in vivo differences between different LEH formulations. These studies will be correlated with any hematological and pathological changes associated with LEH treatment. Development of such non-invasive monitoring techniques may lead to significant cost effective manufacturing and formulation improvements, and ultimately a more efficacious LEH product. The development of this elegant labeling technique should make it possible to study the effect of various LEH modifications on biodistribution non-invasively in primates and humans.


Descriptors :   *IN VIVO ANALYSIS , LIPOSOMES , ANIMALS , HEMOGLOBIN , BLOOD VOLUME , SALINE SOLUTION , BLOOD CELLS , HYPERTONIC


Subject Categories : Biochemistry
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE