Accession Number : ADA261808


Title :   Effects of Space Radiation on Humoral and Cellular Immunity in Rhesus Monkeys.


Descriptive Note : Final rept. May 90-Mar 91,


Corporate Author : TRINITY UNIV SAN ANTONIO TX


Personal Author(s) : Stone, William H ; Miller, Michael L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a261808.pdf


Report Date : Dec 1992


Pagination or Media Count : 21


Abstract : The objective of this study was to complete profiles of immune competence in rhesus monkeys more than 25 years after single exposures to protons of different energies. Access to irradiated animals provided a unique opportunity to study late effects on the immune systems of nonhuman primates; late immunological defects could be relevant to astronauts and high-flying pilots. Working with the primate model allowed us to assess the possible late effects of ionizing radiations on parameters associated with B-cell and T-cell functions. Antibody-mediated immune (AMI) function was investigated by measuring immunoglobulin (Ig) levels, hemolytic complement activity, and autoantibodies. Cell-mediated immune (CMI) function was evaluated by measuring selected T- and B-cell activities as well as responses to mitogens and interleukin production. There were no significant differences between control and irradiated animals for most parameters measured in this survey, but some reduction in spontaneous proliferation was noted in irradiated primates. With regard to late risks for humans following exposure(s) to ionizing radiations, it is encouraging that few late immunobiological effects were exhibited by primate survivors of low and intermediate doses of rotons.... Late effects, Proton irradiation, Immunobiology, Aging.


Descriptors :   *PROTONS , *IMMUNITY , *IONIZING RADIATION , *RHESUS MONKEYS , CONTROL , FUNCTIONS , RISK , PRODUCTION , MODELS , PROFILES , RESPONSE , ANTIBODIES , ROTONS , ASTRONAUTS , IMMUNOGLOBULINS , MONKEYS , PRIMATES , IRRADIATION , ANIMALS , ACCESS , SURVEYS , REDUCTION , HUMANS , PARAMETERS , CELLS , PILOTS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE