Accession Number : ADA261707
Title : Analysis of Dengue Virus Enhancing Epitopes Using Peptide Antigens Derived From the Envelope Glycoprotein Gene Sequence.
Descriptive Note : Final rept. 1 Sep 89-30 Nov 91,
Corporate Author : CENTERS FOR DISEASE CONTROL ATLANTA GA
Personal Author(s) : Chu, May C
Report Date : 29 Nov 1991
Pagination or Media Count : 59
Abstract : The biological events leading to the development of severe disease manifestations of dengue infections (dengue hemorrhagic fever/dengue shock syndrome, DHF/DSS) has been the focus of many investigations. Though DHF/DSS cases occur during primary dengue infections, the majority of severe dengue disease has been associated with persons experiencing a secondary heterotypic dengue infection. What do we know about the pathogenic processes that result in the exacerbation of dengue symptoms? Can these factors be identified in vitro and then correlated with clinical disease? The results of previous studies suggest that preexisting DEN antibodies circulating in a person may be a risk factor in the development of DHF/DSS. However, other host and viral factors must be involved since only a small proportion of the population residing in endemic dengue disease regions develop severe dengue disease.... Dengue fever, Nucleotide sequencing, Peptides, Enhancing epitopes, RA I, PO, Antigens, Dengue virus, Analysis.
Descriptors : *HEMORRHAGIC SHOCK , *DENGUE VIRUS , SECONDARY , SIGNS AND SYMPTOMS , ANTIBODIES , DENGUE , HEMORRHAGIC FEVERS , DECISION SUPPORT SYSTEMS
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE