Accession Number : ADA260987


Title :   Development of a Controlled Release Delivery System for Immunogens


Descriptive Note : Final rept. 15 Aug 89-15 Feb 90,


Corporate Author : DYNAGEN INC CAMBRIDGE MA


Personal Author(s) : Kitchell, Judith P


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a260987.pdf


Report Date : 15 Feb 1990


Pagination or Media Count : 28


Abstract : The development program addresses the problem of effectively protecting military personnel from bacterial, viral, or toxic incapacitation. At the present, logistical problems in carrying out a protective program remain formidable because vaccination programs involve: multiple injections; administration by trained medical personnel; and careful medical record maintenance. An approach to reducing the 'Logistical problems is to modify immunization formulations so that single doses confer complete immunity. The overall program goal is to demonstrate that immunity comparable to that obtained with an initial vaccination plus one booster vaccination can be obtained by simultaneous injection of normal and sleeper vaccine formulations. In Phase I of the program, prototype formulations demonstrated the feasibility of three important facets of the of sleeper concept. One formulation (which did not contain protein) showed that, when subjected to a moist environment, it could remain almost unchanged for about 6 weeks, at which point it rapidly swelled and released many small particles. Another prototype, containing protein, showed delayed protein release properties; and yet a third formulation was used to demonstrate retention of antigenic conformation after processing and exposure to moisture for two weeks.


Descriptors :   *INOCULATION , *IMMUNIZATION , *HEPATITIS , *IMMUNOGENS , MAINTENANCE , INJECTION , MILITARY PERSONNEL , ENVIRONMENTS , MANAGEMENT , THREATS , PROTEINS , FORMULATIONS , COPOLYMERS , PROTOTYPES , PHASE , MISSIONS , PROTECTION , RELEASE , RECORDS , ARMY , MOISTURE , GLYCOLIC ACID , INCAPACITATION , VACCINES , IMMUNITY , MEDICAL PERSONNEL


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE