Accession Number : ADA260874


Title :   The Acute Inhalation Toxicity of Pyrolysis Products of Halon 1301


Descriptive Note : Final rept. 1 Apr 1987-30 Sep 1992


Corporate Author : LOS ALAMOS NATIONAL LAB NM LIFE SCIENCES DIV


Personal Author(s) : Lehnert, Bruce E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a260874.pdf


Report Date : 31 Dec 1992


Pagination or Media Count : 82


Abstract : To develop exposure systems and methodology to deliver pure, stable atmospheres of Hf, HBr, or HCl to laboratory rats. To determine the toxicological equivalency of inhaled HF, HBr, and HCl in the upper and lower respiratory tract. Characterize the anatomical sites of injury caused by HF, HCl, and HBr when inhaled at high mass concentrations through the nasal (NB) and oral (MB) pathways. To assess the relative toxicities of the above halides when inhaled at high mass concentrations during mouth and nose breathing. To characterize the upper and lower respiratory tract lesion(s) produced by HCl inhalation in the nose breathing (NB) and mouth breathing (MB) rats during CO2- induced increased minute ventilation. To examine the toxicity of HF when administered directly into the rat's lung. To determine if work performance incapacitation occurs after acute high concentration inhalation of HCl via the nose (NB) or the mouth (MB). To assess post-exposure exercise as a potentiator of the severity of expression of halide-induced respiratory tract injury. To initiate studies to determine whether or not lung injury becomes more pronounced after halides are breathed in combination with a particulate phase.


Descriptors :   *TOXICITY , *HALIDES , *INHALATION , RESPIRATORY SYSTEM , HYDROGEN CHLORIDE , HYDROGEN FLUORIDE , WOUNDS AND INJURIES , EXPOSURE(PHYSIOLOGY)


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE