Accession Number : ADA260872
Title : Support Between USAMRDC and USDA for Cooperative Research Under the Ration Sustainment Testing Program.
Descriptive Note : Final rept. 1 Jul 91-30 Sep 91,
Corporate Author : DEPARTMENT OF AGRICULTURE WASHINGTON DC
Personal Author(s) : Kramer, T R
Report Date : 31 Dec 1992
Pagination or Media Count : 20
Abstract : We examined the effects of high energy expenditure and hypocaloric intakes during US Army Ranger training on cellular immune functions and systemic cytokine production. Blood samples were collected at baseline (B), and at the end of each of 4 phases, (Benning, I; Mountain, II; Jungle, III; Desert, IV), of training. Mitogen induced T-lymphocyte proliferation was suppressed at the end of Phases I-IV, with the greatest at the end of II and III. Mitogen induced interleukin-2 (IL-2) and soluble IL-2 receptor (IL-2R) levels were only decreased at the end of Phases I and II. Delayed type hypersensitivity (DTH) skin tests were conducted at B and at the end of phases III and IV. Ranger training did not impair the ability of the trainees to express DTH at the end of Phases Ill and IV to infectious microorganisms that they had immunity to at B. Whole-blood produced interleukin-6 (IL-6) in vitro was decreased in the trainees upon completion of Phase III, while plasma IL-6 concentration was increased at the end of Phase I, followed by continued reductions at the end of Phases of II- IV. Compared to B, Ranger training had a profoundly suppressive effect on T- lymphocyte function and systemic circulation of IL-6.... T-lymphocyte proliferation, Interleukin-2, Interleukin-2 receptors, Delayed type hypersensitivity skin test, Interleukin-6.
Descriptors : *T LYMPHOCYTES , *HYPERSENSITIVITY , *SKIN TESTS , TEST AND EVALUATION , FUNCTIONS , PRODUCTION , TRAINING , ENERGY , PHASE , IMMUNITY , CIRCULATION , MICROORGANISMS , BLOOD , LYMPHOCYTES , DESERTS , ARMY , REDUCTION , HIGH ENERGY , MOUNTAINS , JUNGLES , TRAINEES
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE