Accession Number : ADA260864
Title : Human Immunodeficiency Virus (HIV) Infections; Strain and Type Variations; Diagnosis and Prevention.
Descriptive Note : Final rept. 30 Sep 89-29 Sep 92,
Corporate Author : KAROLINSKA INST STOCKHOLM (SWEDEN)
Personal Author(s) : Norrby, Erling ; Fenyo, Eva M
Report Date : 26 Oct 1992
Pagination or Media Count : 39
Abstract : The studies described herein have focused on HIV variability, in particular on biologic and antigenic variability and its relevance for pathogenesis and for development of means for immune intervention. During the third year of the grant period we have intensified studies on molecular variability of HIV-1 and attempted to molecularly map biologic and antigenic determinants. Biologic characterization involved tests for replicative capacity, cytopathic effect and monocyte tropism of virus isolates and molecular clones, whereas antigenic characterization involved virus neutralization in autologous as well as heterologous system. By use of synthetic peptides, epitopes for virus neutralization and antibody dependent cellular cytotoxicity (ADCC) have been mapped in the envelope of HIV-1 and HIV-2. Variable region 3 (V3) of the HIV-1 envelope has been studied in relation to biological and antigenic variation of HIV-1 isolates and in relation to mother-to-child transmission of HIV-1.
Descriptors : *DIAGNOSIS(MEDICINE) , *STRAINS(BIOLOGY) , *INFECTIOUS DISEASES , *HUMAN IMMUNODEFICIENCY VIRUSES , PEPTIDES , MONOCYTES , RIBONUCLEIC ACIDS , CULTURES(BIOLOGY) , MACROPHAGES , MONKEYS , CHAIN REACTIONS , ANTIGENS , CELLS(BIOLOGY) , T LYMPHOCYTES , CLONES , SYNTHESIS(CHEMISTRY) , DEOXYRIBONUCLEIC ACIDS
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE