Accession Number : ADA260193


Title :   Effects of Psychoactive Drugs or Stress on Learning, Memory, and Performance as Assessed Using a Novel Water Maze Task


Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF NEUROPSYCHIATRY


Personal Author(s) : Kant, G J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a260193.pdf


Report Date : Jan 1993


Pagination or Media Count : 10


Abstract : A novel water maze was used to assess the potential performance disrupting effects of psychoactive drugs and stressors (4 mg/kg amphetamine sulfate, 1, 2 or 4 mg/kg diazepam, 30 mg/kg caffeine, 5 or 30 mg/kg atropine sulfate, 15 min of either intermittent footshock, forced running, or immobilization). The task utilized a traditional type of maze with walls and doorways set inside a pool. The apparatus could easily be reconfigured to present different mazes of approximately equal difficulty by opening or closing multiple doorways. one group of rats ran 3 daily trials through the same maze each day to assess memory. The second group was challenged to swim 3 consecutive trials in a new maze configuration each day as a measure of learning. The new maze task was more sensitive than the well-learned maze to the performance disrupting effects of amphetamine, caffeine, and diazepam, while atropine had no significant effect on performance on either maze. Footshock stress impaired performance on both mazes, while the other stressors had no significant effect.


Descriptors :   *MEMORY(PSYCHOLOGY) , *LEARNING , *PSYCHOTROPIC AGENTS , REPRINTS , PERFORMANCE TESTS , ATROPINE , DIAZEPAM , AMPHETAMINES , PROLACTIN , CORTICOSTEROID AGENTS , ADRENOCORTICOTROPIC HORMONE , NEUROPHYSIOLOGY , CAFFEINE , DRUGS , STRESS(PSYCHOLOGY)


Subject Categories : Psychology


Distribution Statement : APPROVED FOR PUBLIC RELEASE