Accession Number : ADA259960


Title :   Pyrodoxine Deficiency and Wound Healing in Rats: Assessment of Antioxidant Enzymes and Immunological Status,


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : Mu, Thornton S ; Dubick, Michael A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259960.pdf


Report Date : Jul 1992


Pagination or Media Count : 19


Abstract : Many nutrients are involved in the complex process of wound healing. Of the vitamins, pyridoxine (vitamin B6) deficiency has resulted in impaired healing, primarily due to its effect on amino acid and protein metabolism. This study examined the effects of pyridoxine deficiency on wound healing and its effects on acute phase proteins, immunoglobulins, and antioxidant enzymes in rats. Female rats were fed diets containing 0 mg/kg (deficient), 0.25 or 1.0 mg/kg (marginally deficient) or 7 mg/kg (control) pyridoxine for 5 weeks. Half the animals in each dietary group received a 3 cm long full skin incisional wound on the back and all animals were euthanized 1 week later. The results showed that despite pyridoxine deficiency, the animals in each dietary group had similar acute phase responses and antioxidant enzyme status in response to the injury... .Pyridoxine, Wound healing, Antioxidant, Rats, Immunoglobulins


Descriptors :   *ENZYMES , *ANTIOXIDANTS , *HEALING , *PYRIDOXINES , *PROTEIN METABOLISM , *IMMUNOGLOBULINS , CONTROL , TISSUES(BIOLOGY) , NUTRIENTS , DEFICIENCIES , WOUNDS AND INJURIES , AMINO ACIDS , FEMALES , DIET , RESPONSE(BIOLOGY) , ANTIBODIES , PHASE , LIPIDS , RATS


Subject Categories : Biochemistry
      Anatomy and Physiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE