Accession Number : ADA259559


Title :   Synthesis and Antiviral Evaluation of N-Carboxamidine-Substituted Analogues of 1-Beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamidine Hydrochloride


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Gabrielsen, Bjarne ; Phelan, Michael J ; Barthel-Rosa, Luis ; See, Cathy ; Huggins, John W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259559.pdf


Report Date : Jan 1992


Pagination or Media Count : 8


Abstract : Ribavirin and its 3-carboxamidine hydrochloride analogue are broad- spectrum antiviral agents which were synthesized and developed nearly concurrently. Both compounds possess efficacy against a broad array of DNA and RNA viruses, are known inhibitors of inosine monophosphate dehydrogenase (IMP) after adenosine-kinase dependent conversion to nucleotides, and, in general, possess similar mechanisms of action. In addition to IMP dehydrogenase, 2A is an effective competitive inhibitor of purine nucleoside phosphorylase.


Descriptors :   *SYNTHESIS , *DRUGS , *ANTIVIRAL AGENTS , METHYL RADICALS , MEDICAL RESEARCH , VIRUSES , RIBONUCLEIC ACIDS , INFLUENZA VIRUS , GLYCINE , PHOSPHORUS TRANSFERASES , INOSINE , VENEZUELAN EQUINE ENCEPHALOMYELITIS VIRUS , JAPANESE ENCEPHALITIS VIRUSES , AMIDINES , ADENOSINE , YELLOW FEVER , CARBOXYL RADICALS , NUCLEOTIDES , MEASLES VIRUSES , DENGUE VIRUS , AMINO ACIDS , HUMAN IMMUNODEFICIENCY VIRUSES , SANDFLY FEVER VIRUS INFECTION , DEOXYRIBONUCLEIC ACIDS , ORGANIC COMPOUNDS , AMIDES


Subject Categories : Biochemistry
      Medicine and Medical Research
      Microbiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE