Accession Number : ADA259552


Title :   Strenuous Exercise Simulating Hepatic Injury during Vaccine Trials


Descriptive Note : Journal article


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Malinoski, F J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259552.pdf


Report Date : Jan 1992


Pagination or Media Count : 4


Abstract : Three healthy young men participating in phase 1 clinical vaccine trials had unexplained increases in their serum transaminase levels. Retrospective analysis indicated that these volunteers had participated in strenuous physical training 2-5 days prior to the noted elevations. The pattern of serum enzyme elevations, initially thought to be consistent with hepatic injury, were associated with parallel increases in creatine phosphokinase. One individual consented to repeat his exercise regimen. This was followed by a recurrence of the same pattern of increases in serum enzymes, including creatine phosphokinase. Thus, in trials where serum enzymes will be measured, it may be prudent to encourage subjects to refrain from increasing their activity above that which they normal perform.... Exercise, Creatine phosphokinase, Hepatic injury, Vaccine trials, Transaminase.


Descriptors :   *EXERCISE(PHYSIOLOGY) , *LIVE VACCINES , *CREATINE PHOSPHOKINASE , ENZYMES , PHASE , PATTERNS , WOUNDS AND INJURIES , ELEVATION


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE