Accession Number : ADA259466


Title :   Immunologic Aspects of Liposomes: Presentation and Processing of Liposomal Protein and Phospholipid Antigens,


Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC DIV OF BIOCHEMISTRY


Personal Author(s) : Alving, Carl R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259466.pdf


Report Date : Jan 1992


Pagination or Media Count : 17


Abstract : In recent years numerous insights into the cellular mechanisms for initiation of the afferent and efferent limbs of the immune response have led to development of exciting theories in a new field that has come to be known as 'antigen presentation'. This field encompasses the cellular mechanisms and processes by which antigenic information is received and translated by the immune system to generate an immune response. Highly sophisticated and useful theories of antigen presentation have been proposed by several laboratories based on research in which virtually all of the investigations were performed with protein or peptide antigens. Many theories even include a requirement for partial degradation of proteins as a vital theoretical element in the basic concept of antigen presentation. One of the major purposes of this review is to describe various ways in which liposomes have been used as models or tools for studying membrane-associated mechanisms that play a role in the induction of immune responses to protein antigens. Liposomes containing protein or peptide antigens have played an important role as models in the development of theories of interactions of membrane-associated protein antigens with antigen presenting cells.


Descriptors :   *LIPOSOMES , *ANTIGENS , *PHOSPHOLIPIDS , REPRINTS , IN VITRO ANALYSIS , CHOLESTEROL , MICE , RECEPTOR SITES(PHYSIOLOGY) , LYMPHOCYTES , IMMUNOLOGY , MONOCLONAL ANTIBODIES , T LYMPHOCYTES , IN VIVO ANALYSIS


Subject Categories : Biochemistry
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE