Accession Number : ADA259309


Title :   Preliminary Assessment of the Relative Toxicity of 1,5-Diazido-3- Nitrazapentane 90-Day Dermal Application Male and Female Rabbits Study Number 75-51-Y809-90, May 1990 - June 1992. Phase 2


Descriptive Note : Final rept. May 90-Jun 92,


Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD


Personal Author(s) : Haight, Everett A ; Harvey, John G , Jr ; Beall, Patricia


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259309.pdf


Report Date : Jun 1992


Pagination or Media Count : 43


Abstract : A 90-day application of DANPE has the potential to cause testicular hypospermatogenesis in male rabbits and an apparent inhibition of mature ovarian follicles formation in female rabbits. A no-observed-adverse-effect-level was not achieved in the male rabbits but was achieved in female rabbits at 27.3 mg/kg dose level.... 1,5-Diazido-3-Nitrazapentane, Dermal, Approximate Lethal Dose (ALD), Testicular hypospermatogenesis, Ovarian follicle No-observed-adverse- effect-level (NOAEL).


Descriptors :   *TOXICITY , *SKIN TESTS , LETHAL DOSAGE , SEX HORMONES


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE