Accession Number : ADA259195


Title :   Retinal Information Processing for Minimum Laser Lesion Detection and Cumulative Damage


Descriptive Note : Final rept. 1 May 1989-30 Apr 1992


Corporate Author : DUKE UNIV DURHAM NC


Personal Author(s) : Wolbarsht, Myron L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259195.pdf


Report Date : 17 Sep 1992


Pagination or Media Count : 24


Abstract : Minimum ophthalmoscopically visual lesions are not . perceived very well by the injured person either from clinical experience or other forms of testing, certainly not with the detail that retinal images of the same size are seen. Previous experiments have suggested a model for retinal organization suitable for small detail detection but which will not detect retinal small lesions very well. Smaller lesions of a sub-threshold nature can cause histological damage but are not visible ophthalmoscopically, nor can they be demonstrated to cause a loss of function. A series of animal experiments has been carried out to test the electrophysiological responses of retinal ganglion cells with sufficient resolution to detect threshold laser exposures with possible deficits in perceiving moving spot/edges and other optical discontinuities. The results are accurate with high resolution and the results should be correlated with supra-threshold exposures of a level to cause sub- retinal hemorrhages and/or vitreous hemorrhages. Both qualitative and quantitative comparisons are needed between the kind of damage caused by sub- threshold, barely threshold, and markedly supra-threshold lesions on this aspect of retinal organization.... RA 3; Lasers; Subretinal hemorrhage; Vitrectomy; Vitreous hemorrhage.


Descriptors :   *RETINA , *LASER DAMAGE , FUNCTIONS , ORGANIZATIONS , DETECTION , DAMAGE , MODELS , CELLS , EDGES , DISCONTINUITIES , HEMORRHAGE , LESIONS , COMPARISON , RESOLUTION , LASERS , HIGH RESOLUTION , RESPONSE , IMAGES , ANIMALS


Subject Categories : Medicine and Medical Research
      Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE